LTELF: Get the latest LS telcom stock price and detailed information including LTELF news, historical charts and realtime prices. Indices Commodities Currencies StocksApixaban tended to be prescribed in older patients with a history of atrial fibrillation rather than those with DVT/PE. The results of this study are in concordance with recently published retrospective studies evaluating the safety and effectiveness of apixaban compared with warfarin in patients in severe renal dysfunction. 17-19,21 ...Apixaban (Eliquis) is the third new oral anticoagulant recently labeled to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. Unlike warfarin ...Objectives Compare the effect of apixaban and warfarin on coagulation and primary haemostasis biomarkers in atrial fibrillation (AF). Methods The biomarker substudy from the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation trial included 4850 patients with AF randomised to treatment with apixaban or warfarin. Sixty per …ELIQUIS (apixaban) is not for patients with artificial heart valves. Spinal or epidural blood clots (hematoma). People who take ELIQUIS, and have medicine injected into their spinal and epidural area, or have a spinal puncture have a risk of forming a blood clot that can cause long-term or permanent loss of the ability to move (paralysis).Randomized trials to date of apixaban versus warfarin for AF excluded patients with severe and end-stage kidney disease, calculated creatinine clearance <25 mL per minute. 4, 5 The US Food and Drug Administration cautiously extended apixaban use to patients with end-stage kidney disease on hemodialysis based on limited pharmacokinetic data. 6 ... elicuis,apixaban Esta página emplea tanto cookies propias como de terceros para recopilar información estadística de su navegación por internet y mostrarle publicidad y/o información relacionada con sus gustos. Apixaban is an oral, direct factor Xa inhibitor that inhibits both free and clot-bound factor Xa, and has been approved for clinical use in several thromboembolic disorders, including reduction of stroke risk in non-valvular atrial fibrillation, thromboprophylaxis following hip or knee replacement surgery, the treatment of deep vein thrombosis or pulmonary embolism, and …Why are oil stocks down today? Well, that can be summed up by the decline in energy prices, the rise in the dollar and the fall in stocks. Why are oil stocks down today? There are ...Apixaban should be discontinued at least 24 hours prior to elective surgery or invasive procedures with a low risk of bleeding. If surgery cannot be delayed, appropriate caution should be exercised, taking into consideration an increased risk of bleeding. This risk of bleeding should be weighed against the urgency of intervention.Apixaban. The 13F moiety intermediate before apixaban was fully developed. During the SAR development of apixaban there were three groups that needed to be tested to attain maximum potency and bioavailability. The first group to be tested was the non-active site as it needs to be stabilized before SAR testing on the p-methoxyphenyl group (S1 ...Aug 14, 2023 · Apixaban se utiliza para disminuir el riesgo de accidente cerebrovascular causado por un coágulo de sangre en las personas con un trastorno del ritmo cardíaco llamado fibrilación auricular. Apixaban también se utiliza después de una cirugía de reemplazo de cadera o rodilla para prevenir un tipo de coágulo sanguíneo llamado trombosis ... Apixaban is an oral anticoagulant and direct inhibitor of factor Xa which is used to decrease the risk of venous thromboses, systemic embolization and stroke in patients with atrial fibrillation, and lower the risk of deep vein thrombosis and pulmonary embolus after knee or hip replacement surgery. Apixaban has been linked to a low rate …Apixaban may cause bleeding in eyes, stomach, nose, etc and anemia which may cause tiredness or paleness. It may also lower your blood pressure which may make you faint or have a quickened heartbeat and nausea. Blood tests may show an increase in gamma glutamyltransferase (GGT), which may be due to liver problems. Q.Eliquis 5mg film coated tablets. Pharmacy Only: Prescription. Company: Bristol-Myers Squibb-Pfizer. Status: Updated. Legal Category: Product subject to medical prescription which may be renewed (B) Active Ingredient(s):Standard-dose apixaban is discovered to have comparable efficacy but improved safety when compared to warfarin, supporting earlier meta-analyses. There is still controversy around the efficacy of reduced-dose apixaban, and more prospective studies are required. The dose of apixaban is a significant influencing factor in its safety and …Apr 6, 2023 · Eliquis (apixaban) is used for blood clots, such as those in deep vein thrombosis (DVT) and atrial fibrillation (AFib). Learn about side effects, dosage, and more. Apixaban is metabolised mainly via CYP3A4/5 with minor contributions from CYP1A2, 2C8, 2C9, 2C19, and 2J2. Unchanged apixaban is the major active substance-related component in human plasma with no active circulating metabolites present. Apixaban is a substrate of transport proteins, P-gp and breast cancer resistance protein (BCRP). ElderlySome negotiations are simply too difficult and complicated to solve traditionally. If the negotiations you’re involved with have come to a stalemate, the “indaba” technique makes i...APIXABAN before any medical procedures (including operations in hospital, minor procedures at GP or dental clinics). Do NOT stop taking your APIXABAN unless told by your doctor. How do I take APIXABAN? Swallow the tablet whole. You can take it with or without food. Your pharmacist can put APIXABAN in a dose administration aid, such as …AVERROES trial. In early 2011, the apixaban versus acetyl-salicylic acid to prevent stroke in atrial fibrillation patients who have failed or are unsuitable for vitamin K antagonist treatment (AVERROES) trial was published. It was a double-blind, randomized-controlled trial comparing the use of apixaban with aspirin (two thirds received low-dose aspirin) for …Apixaban is metabolized mainly via CYP3A4 with minor contributions from CYP1A2, 2C8, 2C9, 2C19, and 2J2. O-demethylation and hydroxylation at the 3-oxopiperidinyl moiety are the major sites of biotransformation. Unchanged apixaban is the major drug-related component in human plasma; there are no active circulating metabolites.Background: Recommendations for apixaban dosing on the basis of kidney function are inconsistent between the US Food and Drug Administration and European Medicines Agency for patients with atrial fibrillation. Optimal apixaban dosing in chronic kidney disease remains unknown. Methods: With the use of deidentified electronic health record data from the …Apixaban produces several metabolites via cytochrome P450 (CYP-450) 3A4–dependent mechanisms. O-demethyl apixaban sulphate, a nonreactive metabolite, is the primary metabolite produced; therefore, the potential for apixaban to form reactive metabolites is expected to be minimal, and apixaban did not prolong the QTc interval in …Nov 21, 2023 · Eliquis (apixaban) and warfarin (generic Coumadin) are both anticoagulants, or blood thinners. Both drugs are approved by the U.S. Food and Drug Administration (FDA) for prescription use. Eliquis is made by Bristol-Myers Squibb. Eliquis is available in brand name only, but a generic will likely be available soon. Apr 6, 2023 · Eliquis (apixaban) is used for blood clots, such as those in deep vein thrombosis (DVT) and atrial fibrillation (AFib). Learn about side effects, dosage, and more. The same info as provided by GPs to patients during consultations,health/disease leaflets,patient support orgs,all about medicines,book GP appts online,interactive patient experien...Apixaban is a novel oral anticoagulant (NOAC) approved by the US Food and Drug Administration (FDA) in 2012 for use in patients with non-valvular atrial fibrillation to reduce the risk of stroke and blood clots. Later, in 2014, it was approved to treat deep venous thrombosis (DVT) and pulmonary embo …Apixaban, an oral factor Xa inhibitor, was approved by the Food and Drug Administration in 2014 for the treatment of venous thromboembolic events and stroke prevention in patients with atrial fibrillation. To date, this is the first biopsy proven case of apixaban-induced AIN. 3–5. Case presentation.Apixaban is a selective factor Xa (FXa) inhibitor that does not require antithrombin for its antithrombotic activity. It inhibits both free and clot-bound FXa as well as prothrombinase activity. It indirectly inhibits platelet aggregation induced by thrombin, and decreases thrombin generation and thus fibrin clot development.Standard-dose apixaban is discovered to have comparable efficacy but improved safety when compared to warfarin, supporting earlier meta-analyses. There is still controversy around the efficacy of reduced-dose apixaban, and more prospective studies are required. The dose of apixaban is a significant influencing factor in its safety and …Apixaban is a prescription medication used to reduce the risk of stroke and systemic embolism (artery blockage). Apixaban belongs to a group of drugs called Xa inhibitor anticoagulants, which decrease the chance of a blood clot forming in the body.ELIQUIS (apixaban) is indicated for prevention of stroke and systemic embolism in adult patients with non-valvular atrial fibrillation (NVAF), with one or more risk factors, such as prior stroke or transient ischaemic attack (TIA), age ≥75 years, hypertension, diabetes mellitus, symptomatic heart failure (NYHA Class ≥II). 1.Dabigatran, rivaroxaban, apixaban, and edoxaban were compared with warfarin for stroke prevention in 4 randomized trials that included 71 683 patients with nonvalvular AF. 43 – 46 In addition, apixaban was compared with aspirin in AF patients who were unable or unwilling to take VKAs. 47 Universal criteria for defining nonvalvular AF are ...Apixaban should be discontinued at least 24 hours prior to elective surgery or invasive procedures with a low risk of bleeding. If surgery cannot be delayed, appropriate caution should be exercised, taking into consideration an increased risk of bleeding. This risk of bleeding should be weighed against the urgency of intervention.The active substance in Eliquis, apixaban, is a ‘factor Xa inhibitor’. This means that it blocks factor Xa, an enzyme that is involved in the production of thrombin. Thrombin is central to the process of blood clotting. By blocking factor Xa, it reduces the levels of thrombin in the blood, which reduces the risk of blood clots forming in ...Similarly, in ARISTOTLE on apixaban, 6.6% of patients enrolled had a history of cancer, while only 0.7% had an active malignancy . Finally, in ENGAGE-AF on edoxaban, patients with cancer were generally excluded, yet a 5.5% of the study population developed active cancer in the course of the trial after a variable time period from study onset ...Eliquis (apixaban) can interact with many commonly used supplements, over-the-counter, and prescription medications. For example, rifampin (Rifadin) and carbamazepine (Tegretol) can lower the levels of Eliquis (apixaban) in your body and put you at higher risk for bleeds. Make sure to tell your provider about all of the medications … If any two of the following: age ≥80yrs; body weight ≤60kg, serum creatinine ≥1.5mg/dL: 2.5mg twice daily. Prophylaxis of DVT: 2.5mg twice daily; give initial dose at 12–24hrs after ... VANCOUVER, BC / ACCESSWIRE / September 28, 2020 / ZincX Resources Corp. ("ZincX Resources" or the "Company") (TSXV:ZNX) is ple... VANCOUVER, BC / ACCESSWIRE / S...Eliquis (apixaban) dosing, indications, interactions, adverse effects, and more. Discontinue at least 24 hr before elective surgery or invasive procedures with low risk of unacceptable bleeding...Apixaban is a medication used to prevent blood clots in certain situations, such as atrial fibrillation or surgery. It can cause serious bleeding and should not be stopped …This video is about Eliquis, a commonly used anticoagulant medicine. The generic name for this is apixaban. Most people with atrial fibrillation have a high ...This website contains UW Medicine recommendations, guidelines, and protocols for treating and preventing venous and arterial thrombosis, and the clinical use of antithrombotic agents in ambulatory and inpatient settings. The UW Medicine Department of Pharmacy operates UW Medicine Anticoagulation Services and collaborates with multidisciplinary ...- Advantages and disadvantages of oral anticoagulants - LMW heparin dosing renal insufficiency (adults) - Anticoagulant dose adjustment in liver disease - Possible contraindications to anticoagulation - Standard dosing of DOACs - DOACs PK and drug interactions - Inhibitors and inducers of P-glycoprotein drug efflux - DOAC absorption …Apixaban is also used to prevent stroke and blood clots in patients with certain heart rhythm problem (eg, nonvalvular atrial fibrillation). Apixaban is a factor Xa inhibitor, an anticoagulant. It works by decreasing the clotting ability of the blood and helps preventing harmful clots from forming in the blood vessels.Elixaban 5mg Tablet is a medicine known as an anticoagulant or blood thinner. It helps prevent and treat blood clots. It prevents and treats clot formation in the veins of your legs, lungs, brain, and heart. It is used to reduce the risk of stroke and heart attack. Elixaban 5mg Tablet is commonly used in patients with irregular heart rhythm ...Apixaban is a frequently used alternative to warfarin in patients with ESRD receiving dialysis due to pharmacokinetic data and increasing experience with its use in this patient population. Many providers have become comfortable with the use of apixaban in renal dysfunction, including with its dose adjustments and use of apixaban may continue ...Another trial with apixaban, the AVERROES trial comparing apixaban with aspirin in patients with AF unsuitable for warfarin, was prematurely terminated because of a 50% reduction in the rate of stroke without any differences in major bleeding. 17 The superiority of apixaban when compared with aspirin with respect to the primary efficacy … Apixaban is a type of medicine known as an anticoagulant. It makes your blood flow through your veins more easily, which means your blood is less likely to make blood clots. It's used to treat people who have had a health problem caused by a blood clot, such as: It's also used to prevent blood clots if you're at high risk of having them in the ... Standard-dose apixaban is discovered to have comparable efficacy but improved safety when compared to warfarin, supporting earlier meta-analyses. There is still controversy around the efficacy of reduced-dose apixaban, and more prospective studies are required. The dose of apixaban is a significant influencing factor in its safety and …Elixaban 5mg Tablet is a medicine known as an anticoagulant or blood thinner. It helps prevent and treat blood clots. It prevents and treats clot formation in the veins of your legs, lungs, brain, and heart. It is used to reduce the risk of stroke and heart attack. Elixaban 5mg Tablet is commonly used in patients with irregular heart rhythm ...Jun 9, 2023 · Apixaban is also used to prevent stroke and blood clots in patients with certain heart rhythm problem (eg, nonvalvular atrial fibrillation). Apixaban is a factor Xa inhibitor, an anticoagulant. It works by decreasing the clotting ability of the blood and helps preventing harmful clots from forming in the blood vessels. Conclusion: Among patients with AF, apixaban use was associated with lower risk for GIB and similar rates of ischemic stroke or systemic embolism, ICH, and all-cause mortality compared with dabigatran, edoxaban, and rivaroxaban. This finding was consistent for patients aged 80 years or older and those with chronic kidney disease, who are often ...ELIQUIS (apixaban) is not for patients with artificial heart valves. Spinal or epidural blood clots (hematoma). People who take ELIQUIS, and have medicine injected into their spinal and epidural area, or have a spinal puncture have a risk of forming a blood clot that can cause long-term or permanent loss of the ability to move (paralysis).Jun 15, 2021 · Crushed apixaban tablets are stable in water, D5W, apple juice, and applesauce for up to 4 hours. 2.5mg, yellow, round, film coated biconvex tablets debossed with "C31" on one side and plain on the other side. 5 mg, pink, oval, film coated biconvex tablets debossed with "C32"on one side and ... The active substance in Eliquis, apixaban, is a ‘factor Xa inhibitor’. This means that it blocks factor Xa, an enzyme that is involved in the production of thrombin. Thrombin is central to the process of blood clotting. By blocking factor Xa, it reduces the levels of thrombin in the blood, which reduces the risk of blood clots forming in ...A nursing mother who was 23 months postpartum received 2 doses of 5 mg of oral apixaban 12 hours apart. Blood and milk samples were obtained before the first dose and at 3.5, 7, 12 (before the second dose), 16, and 24 hours after the first dose. Peak apixaban milk levels of about 230 mcg/L occurred at 3.5 to 4 hours after each dose.FT TOP THEMES ETF MODEL 2 CA- Performance charts including intraday, historical charts and prices and keydata. Indices Commodities Currencies StocksApr 5, 2023 · hives, itching, skin rash. joint pain or swelling. nausea and vomiting. nosebleeds. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue. redness of the eye. severe stomach pain. shortness of breath. tightness in the chest. May 29, 2013 · Apixaban produces several metabolites via cytochrome P450 (CYP-450) 3A4–dependent mechanisms. O-demethyl apixaban sulphate, a nonreactive metabolite, is the primary metabolite produced; therefore, the potential for apixaban to form reactive metabolites is expected to be minimal, and apixaban did not prolong the QTc interval in healthy ... They do this by reducing the ability of the blood to clot. Apixaban is used to prevent blood clots for people who have had total hip replacement or knee replacement surgery. It may also be used to prevent stroke or blood clots in people with atrial fibrillation (a type of abnormal heart rhythm). Apixaban is also used to treat and prevent clots ...Apixaban is a novel oral anticoagulant which has been developed and clinically investigated for prevention of stroke in AF patients. This review discusses the pharmacological properties, results of clinical trials investigating role of apixaban for prevention of stroke and its future potential in clinical practice.Eliquis (Apixaban) is a medication that prevents blood clots and strokes. It can be very expensive, but you can save money with GoodRx coupons and discounts. Find out how much you can save on Eliquis and compare prices at different pharmacies with GoodRx.Get ratings and reviews for the top 11 gutter companies in Annandale, VA. Helping you find the best gutter companies for the job. Expert Advice On Improving Your Home All Projects ...The use of direct oral anticoagulants for stroke prevention in atrial fibrillation continues to rise. Certain populations may be at higher risk for increased drug exposure and adverse events. Pharmacokinetic studies suggest increased exposure of rivaroxaban and apixaban with combined P-gp and modera …Below is a text only representation of the Patient Information Leaflet (ePIL). The text only version may be available in large print, Braille or audio CD . For further information call emc accessibility on 0800 198 5000 . The product code (s) for this leaflet is: PLGB 54213/0002. Print patient leaflet as text only.WARNING: (A) PREMATURE DISCONTINUATION OF ELIQUIS INCREASES THE RISK OF THROMBOTIC EVENTS, (B) SPINAL/EPIDURAL HEMATOMA (A) Premature discontinuation of any oral anticoagulant, including ELIQUIS ® (apixaban), increases the risk of thrombotic events.If anticoagulation with ELIQUIS is discontinued for a reason …Apixaban is an oral direct FXa inhibitor, approved by the FDA for thromboembolism prophylaxis after THA and TKA. Apixaban does not require routine laboratory monitoring for its anticoagulant effect, but it is contraindicated in patients with severe renal impairment (CrCl <15 ml/min).Apr 6, 2023 · Apixaban is a prescription blood thinning medication used to prevent blood clots in the heart and strokes in patients with atrial fibrillation (AFib, AF), and to prevent and treat deep vein thrombosis (DVT) and pulmonary embolism. The most common side effects of apixaban involves bleeding in the stomach, intestines, brain, and eyes. Bleeding due to apixaban may be fatal. Breathing in sync with your partner can improve your mental well-being and help you understand your partner's needs in the present moment. Practicing mindfulness and breathing exer...Aug 15, 2023 · Patients receiving over 2.5 mg orally 2 times a day: Reduce dose by 50%. Patients receiving 2.5 mg orally 2 times a day: Avoid coadministration. Nonvalvular atrial fibrillation patients: Reduce dose to 2.5 mg orally 2 times a day for patients with any 2 of the following: Age 80 years or older. Body weight 60 kg or less. Eliquis 5mg plėvele dengtos tabletės N60. Preparato charakteristikų santrauką sveikatos priežiūros specialistai gali peržiūrėti jiems skirtame elektroniniame vaistų žinyne gydytojams.vaistai.lt. 100%. 50%. factor edoxaban kelio venų plaučių kraujodarą vaistai. Apixaban, also known as Eliquis ®, is a prescribed anticoagulant medication (sometimes called a blood thinner). It’s part of a class of medications called direct oral anticoagulants (DOACs). Apixaban is used to treat blood clots (or prevent new ones from forming) in patients with: Nonvalvular atrial fibrillation (NVAF, which refers to atrial ...Apixaban (Eliquis) is a blood thinner that prevents or treats blood clots and lowers the risk of stroke in people with AFib. Learn about its uses, side effects, interactions, and …Modify Therapy/Monitor Closely. Apixaban is a both CYP3A4 and P-gp substrate. For patients receiving apixaban 5 or 10 mg BID, decrease apixaban dose by 50% when coadministered with drugs that are both P-gp and strong CYP3A4 inhibitors. For patients receiving apixaban 5 mg BID, avoid coadministration with combined P-gp and strong …Eliquis 5 mg plėvele dengtos tabletės. apiksabanas. Atidžiai perskaitykite visą šį lapelį, prieš pradėdami vartoti vaistą, nes jame pateikiama Jums svarbi informacija. Neišmeskite šio lapelio, nes vėl gali prireikti jį perskaityti. Jeigu kiltų daugiau klausimų, kreipkitės į gydytoją, vaistininką arba slaugytoją.High Alert: Do not confuse apixaban with axitinib. When converting from warfarin , discontinue warfarin and start apixaban when INR is <2.0.; When converting from apixaban to warfarin , apixaban affects INR, so INR measurements may not be useful for determining appropriate dose of warfarin.If continuous anticoagulation is necessary, discontinue …Apr 19, 2023 · Apixaban is a novel oral anticoagulant (NOAC) approved by the US Food and Drug Administration (FDA) in 2012 for use in patients with non-valvular atrial fibrillation to reduce the risk of stroke and blood clots. Later, in 2014, it was approved to treat deep venous thrombosis (DVT) and pulmonary embolism (PE). In 2014, it was also approved for use to reduce the risk of blood clots (DVT and PE ...
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3 avoid apixaban use in patients on long-term phenobarbital; the UW Medicine Phenobarbital Protocol for Alcohol Withdrawal Syndrome is a short course, lessening the risk of inducing apixaban metabolism as it typically takes at least 5-7 days to produce maximal induction THIS NEWS RELEASE IS INTENDED FOR DISTRIBUTION IN CANADA ONLY AND IS NOT INTENDED FOR DISTRIBUTION TO UNITED STATES NEWSWIRE SERVICES OR DISSEMINA... THIS NEWS RELEASE IS INTENDED ...CONCLUSIONS: Compared with 2.5 mg, use of 5 mg apixaban was associated with a higher risk of bleeding in patients with atrial fibrillation and severe chronic kidney disease, with no difference in the risk of stroke/systemic embolism or death, supporting the apixaban dosing recommendations on the basis of kidney function by the …Dec 16, 2021 · Apixaban is metabolized mainly via CYP3A4 with minor contributions from CYP1A2, 2C8, 2C9, 2C19, and 2J2. O-demethylation and hydroxylation at the 3-oxopiperidinyl moiety are the major sites of biotransformation. Unchanged apixaban is the major drug-related component in human plasma; there are no active circulating metabolites. Background: There is a plethora of real-world data on the safety and effectiveness of direct-acting oral anticoagulants (DOACs); however, study heterogeneity has contributed to inconsistent findings. We compared the effectiveness and safety of apixaban with those of other direct-acting oral anticoagulants (DOACs) and vitamin K …France continues to ease restrictions leading up to its June 9 reopening to tourists. Here's what you need to know. The Louvre and Versailles are about to throw open their doors on...Nephrotic syndrome (NS) is associated with an elevated risk of venous thromboembolism (VTE), occurring in up to 25% of NS patients.1-3 Guidelines advocate for primary thromboprophylaxis in select NS patients.4 …Methods: The RENAL-AF trial (Renal Hemodialysis Patients Allocated Apixaban Versus Warfarin in Atrial Fibrillation) was a prospective, randomized, open-label, blinded-outcome evaluation (PROBE) of … Active bleeding; significant risk of major bleeding (e.g. recent gastro-intestinal ulcer, oesophageal varices, recent brain, spine, or ophthalmic surgery, recent intracranial haemorrhage, malignant neoplasms, vascular aneurysm). Apixaban is not licensed for use in patients with prosthetic heart valves. Apixaban is contraindicated in severe ... Apixaban is a frequently used alternative to warfarin in patients with ESRD receiving dialysis due to pharmacokinetic data and increasing experience with its use in this patient population. Many providers have become comfortable with the use of apixaban in renal dysfunction, including with its dose adjustments and use of apixaban may continue ...Conclusion: Andexanet alfa may be used for urgent or emergent reversal of apixaban and rivaroxaban peri-procedurally with promising hemostatic outcomes. Further prospective, comparative clinical research is warranted. Keywords: anticoagulation reversal; anticoagulation reversal agents; factor Xa; factor Xa inhibitors; general surgery ...Transitioning from apixaban to unfractionated heparin continuous infusion, low-molecular-weight heparin, or fondaparinux: Start the parenteral anticoagulant when the next dose of apixaban was scheduled to be given. Transitioning from apixaban to warfarin: Apixaban can elevate the INR, complicating interpretation if overlapped with warfarin. To ...Apr 5, 2023 · hives, itching, skin rash. joint pain or swelling. nausea and vomiting. nosebleeds. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue. redness of the eye. severe stomach pain. shortness of breath. tightness in the chest. Apixaban tended to be prescribed in older patients with a history of atrial fibrillation rather than those with DVT/PE. The results of this study are in concordance with recently published retrospective studies evaluating the safety and effectiveness of apixaban compared with warfarin in patients in severe renal dysfunction. 17-19,21 ...of ELIQUIS® (apixaban) patients received this dose. serum creatinine ≥1.5 mg/dl body weight ≤60 kg 5 mg twice daily 2.5 mg twice daily Dosing Considerations in NVAF Patients With Renal Impairment 5 mg taken orally twice daily recommended for most NVAF patients a b c Please see additional Important Safety Information throughout. Please see full 3 avoid apixaban use in patients on long-term phenobarbital; the UW Medicine Phenobarbital Protocol for Alcohol Withdrawal Syndrome is a short course, lessening the risk of inducing apixaban metabolism as it typically takes at least 5-7 days to produce maximal induction .